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Antidepressants increased the risk of suicidal thinking and behavior in short-term studies in children and adolescents with depression and other psychiatric disordersAnyone considering the use of any antidepressant in a child or adolescent must balance this risk with the clinical needPatients who are started on therapy should be closely observed for clinical worseningsuicidal thinking or behaviorand unusual changes in behavior.

Do not use this medicine if you have used an MAO inhibitor in the past 14 dayssuch as isocarboxazidlinezolidmethylene blue injectionphenelzinerasagilineselegilineor tranylcypromine.

The risk of QT prolongation may be increased if you have certain medical conditions or are taking other drugs that may cause QT prolongationBefore using doxepintell your doctor or pharmacist of all the drugs you take and if you have any of the following conditionscertain heart problemsheart failureslow heartbeatQT prolongation in the EKGfamily history of certain heart problemsQT prolongation in the EKGsudden cardiac death

Anti-anxiety effect is apparent before the antidepressant effectOptimal antidepressant effect may not be evident for two to three weeks.

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