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Store viramune at room temperature, between 59 to 86 f 15 to 30 c .
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Patients who interrupt nevirapine dosing for more than 7 days should restart the recommended dosing regimen using the two week lead-in period.
There are toxicities that require interruption of Viramune therapysee section 4.4
Herbal preparations containing StJohn’s Wort and Viramune must not be co-administeredsee section 4.3If a patient is already taking StJohn’s Wort check nevirapine and if possible viral levels and stop StJohn’s WortNevirapine levels may increase on stopping StJohn’s WortThe dose of Viramune may need adjustingThe inducing effect may persist for at least 2 weeks after cessation of treatment with StJohn’s Wort.
Serum levels of nevirapine can be reduced by concomitant use of the herbal preparation StJohn’s WortHypericum perforatumThis is due to induction of medicinal product metabolism enzymes and/or transport proteins by StJohn’s Wort.
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inform patients that they should not take viramune tablets or oral suspension and viramune xr extended release tablets at the same time.