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Take this medication by mouth as directed by your doctorusually once or twice a day after a mealIf you take this drug too close to bedtimeyou may need to wake up to urinateIt is best to take this medication at least 4 hours before your bedtime.

Edema during pregnancy may arise from pathological causes or from the physiologic and mechanical consequences of pregnancyThiazides are indicated in pregnancy when edema is due to pathologic causesjust as they are in the absence of pregnancyDependent edema in pregnancyresulting from restriction of venous return by the expanded uterusis properly treated through elevation of the lower extremities and use of support hoseuse of diuretics to lower intravascular volume in this case is illogical and unnecessaryThere is hypervolemia during normal pregnancy which is harmful to neither the fetus nor the motherin the absence of cardiovascular diseasebut which is associated with edemaincluding generalized edemain the majority of pregnant womenIf this edema produces discomfortincreased recumbency will often provide reliefIn rare instancesthis edema may cause extreme discomfort which is not relieved by restIn these casesa short course of diuretics may provide relief and may be appropriate.

Fluid and electrolyte imbalances are the most important concernExcessive doses of the triamterene component may elicit hyperkalemiadehydrationnauseavomiting and weakness and possibly hypotensionOverdosing with hydrochlorothiazide has been associated with hypokalemiahypochloremiahyponatremiadehydrationlethargymay progress to comaand gastrointestinal irritationTreatment is symptomatic and supportiveTherapy with MAXZIDEtriamterene and hydrochlorothiazideshould be discontinuedInduce emesis or institute gastric lavageMonitor serum electrolyte levels and fluid balance.

A very serious allergic reaction to this drug is rareHoweverget medical help right away if you notice any symptoms of a serious allergic reactionincludingrashitching/swellingespecially of the face/tongue/throatsevere dizzinesstrouble breathing.

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